Drug interactions
Metoprolol + Triamterene
Severity: Moderate
Metoprolol and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can modestly raise serum potassium by impairing cellular uptake of potassium. Combined with the potassium-sparing diuretic triamterene, this adds to the risk of hyperkalemia, particularly in patients with renal impairment or diabetes.
What this interaction means in plain words
Metoprolol and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoprolol belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene blocks renal epithelial sodium channels and reduces potassium excretion, while beta-blockade reduces beta-2 mediated cellular potassium uptake.
What to do
Monitor serum potassium and renal function when starting or adjusting therapy, especially in patients with renal impairment or diabetes. Reduce or stop triamterene if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metoprolol with Triamterene?
MediHelp rates the interaction as moderate. Metoprolol and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can modestly raise serum potassium by impairing cellular uptake of potassium. Combined with the potassium-sparing diuretic triamterene, this adds to the risk of hyperkalemia, particularly in patients with renal impairment or diabetes.
How serious is the interaction between Metoprolol and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function when starting or adjusting therapy, especially in patients with renal impairment or diabetes. Reduce or stop triamterene if potassium rises.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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