Drug interactions
Metreleptin + Tolazamide
Severity: Moderate
Metreleptin and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metreleptin improves insulin sensitivity, and combined with insulin secretagogues such as sulfonylureas it can cause hypoglycemia. Dose reduction of the secretagogue may be required.
What this interaction means in plain words
Metreleptin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metreleptin belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive glucose lowering from improved insulin sensitivity and sulfonylurea-induced insulin secretion.
What to do
Monitor blood glucose closely after starting metreleptin and reduce the tolazamide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Metreleptin
Frequently asked questions
Can I take Metreleptin with Tolazamide?
MediHelp rates the interaction as moderate. Metreleptin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metreleptin improves insulin sensitivity, and combined with insulin secretagogues such as sulfonylureas it can cause hypoglycemia. Dose reduction of the secretagogue may be required.
How serious is the interaction between Metreleptin and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely after starting metreleptin and reduce the tolazamide dose as needed.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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