Drug interactions
Metreleptin + Warfarin
Severity: Moderate
Metreleptin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metreleptin treatment may alter CYP450 enzyme activity as metabolic status improves, changing warfarin clearance and INR. This may raise bleeding risk or reduce anticoagulation.
What this interaction means in plain words
Metreleptin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metreleptin belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
Leptin/metreleptin may modulate CYP450 expression, and improved metabolic control can normalize suppressed enzyme activity.
What to do
Check INR more often when metreleptin is started, changed or stopped, and adjust the warfarin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metreleptin
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Metreleptin with Warfarin?
MediHelp rates the interaction as moderate. Metreleptin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metreleptin treatment may alter CYP450 enzyme activity as metabolic status improves, changing warfarin clearance and INR. This may raise bleeding risk or reduce anticoagulation.
How serious is the interaction between Metreleptin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more often when metreleptin is started, changed or stopped, and adjust the warfarin dose accordingly.
What other medicines interact with Metreleptin?
MediHelp also lists interactions of Metreleptin with, for example, Insulin aspart, Insulin glargine-lixisenatide, Insulin glargine. The full list is on the Metreleptin page.
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