Drug interactions
Metronidazole + Omaveloxolone
Severity: Moderate
Metronidazole and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is metabolized largely by CYP3A4, and moderate or strong inhibitors raise its exposure and the risk of liver enzyme elevation. Metronidazole is a weak inhibitor, so the effect is probably modest.
What this interaction means in plain words
Metronidazole and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metronidazole belongs to Anti Parasitic; Omaveloxolone belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole reducing omaveloxolone clearance.
What to do
Monitor liver enzymes and bilirubin during co-treatment. Reduce the omaveloxolone dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Metronidazole with Omaveloxolone?
MediHelp rates the interaction as moderate. Metronidazole and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone is metabolized largely by CYP3A4, and moderate or strong inhibitors raise its exposure and the risk of liver enzyme elevation. Metronidazole is a weak inhibitor, so the effect is probably modest.
How serious is the interaction between Metronidazole and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin during co-treatment. Reduce the omaveloxolone dose if adverse effects occur.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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