Drug interactions
Metronidazole + Palbociclib
Severity: Minor
Metronidazole and Palbociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is metabolized by CYP3A4, and strong inhibitors raise its exposure and neutropenia risk. Metronidazole is not a strong inhibitor, so any increase is expected to be small.
What this interaction means in plain words
Metronidazole and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Palbociclib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole slightly reducing palbociclib clearance.
What to do
No dose change is needed; follow routine blood counts for neutropenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Palbociclib
Frequently asked questions
Can I take Metronidazole with Palbociclib?
MediHelp rates the interaction as minor. Metronidazole and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Palbociclib is metabolized by CYP3A4, and strong inhibitors raise its exposure and neutropenia risk. Metronidazole is not a strong inhibitor, so any increase is expected to be small.
How serious is the interaction between Metronidazole and Palbociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; follow routine blood counts for neutropenia.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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