Drug interactions
Metronidazole + Ranolazine
Severity: Minor
Metronidazole and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole is only a weak CYP3A4 inhibitor, so any rise in ranolazine concentration is expected to be small. Ranolazine can cause QT prolongation, so monitoring is still sensible in susceptible patients.
What this interaction means in plain words
Metronidazole and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Ranolazine belongs to Cardiovascular.
Why it happens
Weak, poorly established CYP3A4 inhibition may slightly reduce ranolazine clearance.
What to do
No routine dose adjustment is needed. Watch for dizziness, nausea or QT-related symptoms in patients with additional risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Metronidazole with Ranolazine?
MediHelp rates the interaction as minor. Metronidazole and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole is only a weak CYP3A4 inhibitor, so any rise in ranolazine concentration is expected to be small. Ranolazine can cause QT prolongation, so monitoring is still sensible in susceptible patients.
How serious is the interaction between Metronidazole and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Watch for dizziness, nausea or QT-related symptoms in patients with additional risk factors.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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