Drug interactions
Metronidazole + Repotrectinib
Severity: Moderate
Metronidazole and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is metabolized by CYP3A4, and inhibitors raise its exposure and risks such as dizziness, ataxia and other neurologic effects. Metronidazole is a weak inhibitor, so the effect is probably limited.
What this interaction means in plain words
Metronidazole and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metronidazole belongs to Anti Parasitic; Repotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole reducing repotrectinib metabolism.
What to do
Monitor for neurologic adverse effects such as dizziness and ataxia. Reduce the repotrectinib dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metronidazole and Repotrectinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Metronidazole with Repotrectinib?
MediHelp rates the interaction as moderate. Metronidazole and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib is metabolized by CYP3A4, and inhibitors raise its exposure and risks such as dizziness, ataxia and other neurologic effects. Metronidazole is a weak inhibitor, so the effect is probably limited.
How serious is the interaction between Metronidazole and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurologic adverse effects such as dizziness and ataxia. Reduce the repotrectinib dose if they occur.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
