Drug interactions
Metronidazole + Ruxolitinib
Severity: Minor
Metronidazole and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ruxolitinib is metabolized mainly by CYP3A4, and stronger inhibitors increase exposure and cytopenias. Metronidazole is a weak inhibitor and a notable effect is not expected.
What this interaction means in plain words
Metronidazole and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Ruxolitinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole slightly raising ruxolitinib levels.
What to do
No dose adjustment is needed; continue routine blood count monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Metronidazole with Ruxolitinib?
MediHelp rates the interaction as minor. Metronidazole and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ruxolitinib is metabolized mainly by CYP3A4, and stronger inhibitors increase exposure and cytopenias. Metronidazole is a weak inhibitor and a notable effect is not expected.
How serious is the interaction between Metronidazole and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; continue routine blood count monitoring.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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