Drug interactions
Metronidazole + Temsirolimus
Severity: Minor
Metronidazole and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, so inhibition may raise exposure and toxicity such as mucositis, cytopenias and hyperglycemia. Metronidazole is a weak inhibitor, so an important effect is unlikely.
What this interaction means in plain words
Metronidazole and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Temsirolimus belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole reducing temsirolimus metabolism.
What to do
No dose change is needed; monitor for mucositis, cytopenias and glucose abnormalities.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Metronidazole with Temsirolimus?
MediHelp rates the interaction as minor. Metronidazole and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, so inhibition may raise exposure and toxicity such as mucositis, cytopenias and hyperglycemia. Metronidazole is a weak inhibitor, so an important effect is unlikely.
How serious is the interaction between Metronidazole and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for mucositis, cytopenias and glucose abnormalities.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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