Drug interactions
Metronidazole + Trazodone
Severity: Minor
Metronidazole and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is metabolized by CYP3A4, so inhibition could raise levels and increase sedation, hypotension and QT effects. Metronidazole is a weak inhibitor so the effect is likely modest.
What this interaction means in plain words
Metronidazole and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Trazodone belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole reducing trazodone clearance.
What to do
No dose change is usually needed; monitor for excessive sedation and orthostatic hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Metronidazole with Trazodone?
MediHelp rates the interaction as minor. Metronidazole and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone is metabolized by CYP3A4, so inhibition could raise levels and increase sedation, hypotension and QT effects. Metronidazole is a weak inhibitor so the effect is likely modest.
How serious is the interaction between Metronidazole and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for excessive sedation and orthostatic hypotension.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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