Drug interactions
Metyrapone + Prednisone
Severity: Moderate
Metyrapone and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrapone inhibits cortisol synthesis and its effect is judged by cortisol and ACTH response. Exogenous prednisone suppresses the pituitary-adrenal axis and cross-reacts in some cortisol assays, so it can invalidate the metyrapone test and blunt its effect.
What this interaction means in plain words
Metyrapone and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metyrapone belongs to Endocrine; Prednisone belongs to Endocrine.
Why it happens
Exogenous glucocorticoid suppresses ACTH feedback and counteracts cortisol lowering, interfering with metyrapone testing and therapy.
What to do
Avoid giving prednisone around a metyrapone stimulation test unless required. If used for adrenal insufficiency during therapy, use a regimen guided by an endocrinologist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Metyrapone
- Metyrapone + Pacritinib Major
- Budesonide + Metyrapone Moderate
- Cortisone + Metyrapone Moderate
- Cyproheptadine + Metyrapone Moderate
- Deflazacort + Metyrapone Moderate
- Desogestrel-ethinyl estradiol + Metyrapone Moderate
Frequently asked questions
Can I take Metyrapone with Prednisone?
MediHelp rates the interaction as moderate. Metyrapone and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metyrapone inhibits cortisol synthesis and its effect is judged by cortisol and ACTH response. Exogenous prednisone suppresses the pituitary-adrenal axis and cross-reacts in some cortisol assays, so it can invalidate the metyrapone test and blunt its effect.
How serious is the interaction between Metyrapone and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving prednisone around a metyrapone stimulation test unless required. If used for adrenal insufficiency during therapy, use a regimen guided by an endocrinologist.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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