Drug interactions
Mexiletine + Sertraline
Severity: Minor
Mexiletine and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mexiletine is partly metabolized by CYP2D6, and sertraline is a weak to moderate dose-dependent inhibitor of this enzyme. Mexiletine levels may rise modestly, increasing the chance of dose-related effects such as dizziness, tremor, nausea or arrhythmia.
What this interaction means in plain words
Mexiletine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mexiletine belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Sertraline inhibits CYP2D6, reducing mexiletine metabolism.
What to do
Monitor for mexiletine toxicity when starting or increasing sertraline, especially at higher sertraline doses, and reduce the mexiletine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mexiletine and Sertraline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Mexiletine with Sertraline?
MediHelp rates the interaction as minor. Mexiletine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mexiletine is partly metabolized by CYP2D6, and sertraline is a weak to moderate dose-dependent inhibitor of this enzyme. Mexiletine levels may rise modestly, increasing the chance of dose-related effects such as dizziness, tremor, nausea or arrhythmia.
How serious is the interaction between Mexiletine and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mexiletine toxicity when starting or increasing sertraline, especially at higher sertraline doses, and reduce the mexiletine dose if needed.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
