Drug interactions
Micafungin + Midazolam intranasal
Severity: Minor
Micafungin and Midazolam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a sensitive CYP3A4 substrate, so even weak inhibitors can increase exposure and prolong sedation. Micafungin has little proven effect on CYP3A4 in practice, so any increase is likely small.
What this interaction means in plain words
Micafungin and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition by micafungin decreasing midazolam clearance.
What to do
Monitor sedation level and respiratory status after intranasal midazolam; no dose change is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Micafungin
- Lomitapide + Micafungin Moderate
- Micafungin + Saccharomyces boulardii Moderate
- Micafungin + Sirolimus Moderate
- Avapritinib + Micafungin Minor
- Finerenone + Micafungin Minor
- Isavuconazonium + Micafungin Minor
Frequently asked questions
Can I take Micafungin with Midazolam intranasal?
MediHelp rates the interaction as minor. Micafungin and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midazolam is a sensitive CYP3A4 substrate, so even weak inhibitors can increase exposure and prolong sedation. Micafungin has little proven effect on CYP3A4 in practice, so any increase is likely small.
How serious is the interaction between Micafungin and Midazolam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status after intranasal midazolam; no dose change is routinely needed.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Lomitapide, Saccharomyces boulardii, Sirolimus. The full list is on the Micafungin page.
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