Drug interactions
Avapritinib + Micafungin
Severity: Minor
Avapritinib and Micafungin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Micafungin is a weak CYP3A4 inhibitor in vitro and may modestly raise avapritinib exposure. Clinically significant changes are not well documented, but higher avapritinib levels could increase adverse effects such as cognitive effects and bleeding.
What this interaction means in plain words
Avapritinib and Micafungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Micafungin belongs to Anti Fungals.
Why it happens
Possible weak inhibition of CYP3A4-mediated avapritinib metabolism by micafungin.
What to do
No dose change is usually needed; monitor for avapritinib adverse effects such as cognitive changes, edema and bleeding when starting micafungin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Micafungin
- Lomitapide + Micafungin Moderate
- Micafungin + Saccharomyces boulardii Moderate
- Micafungin + Sirolimus Moderate
- Finerenone + Micafungin Minor
- Isavuconazonium + Micafungin Minor
- Ivacaftor + Micafungin Minor
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Micafungin?
MediHelp rates the interaction as minor. Avapritinib and Micafungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Micafungin is a weak CYP3A4 inhibitor in vitro and may modestly raise avapritinib exposure. Clinically significant changes are not well documented, but higher avapritinib levels could increase adverse effects such as cognitive effects and bleeding.
How serious is the interaction between Avapritinib and Micafungin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for avapritinib adverse effects such as cognitive changes, edema and bleeding when starting micafungin.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Lomitapide, Saccharomyces boulardii, Sirolimus. The full list is on the Micafungin page.
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