Drug interactions
Micafungin + Sirolimus
Severity: Moderate
Micafungin and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Micafungin modestly increases sirolimus exposure in healthy volunteer data. Higher sirolimus levels may increase the risk of hyperlipidemia, cytopenias, impaired wound healing and mucositis.
What this interaction means in plain words
Micafungin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Micafungin belongs to Anti Fungals; Sirolimus belongs to Miscellaneous.
Why it happens
Probable weak inhibition of CYP3A4-mediated sirolimus metabolism; the mechanism is not fully established.
What to do
Monitor sirolimus trough concentrations when micafungin is started or stopped. Adjust the sirolimus dose according to levels and signs of toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Micafungin
- Lomitapide + Micafungin Moderate
- Micafungin + Saccharomyces boulardii Moderate
- Avapritinib + Micafungin Minor
- Finerenone + Micafungin Minor
- Isavuconazonium + Micafungin Minor
- Ivacaftor + Micafungin Minor
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Micafungin with Sirolimus?
MediHelp rates the interaction as moderate. Micafungin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Micafungin modestly increases sirolimus exposure in healthy volunteer data. Higher sirolimus levels may increase the risk of hyperlipidemia, cytopenias, impaired wound healing and mucositis.
How serious is the interaction between Micafungin and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations when micafungin is started or stopped. Adjust the sirolimus dose according to levels and signs of toxicity.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Lomitapide, Saccharomyces boulardii, Avapritinib. The full list is on the Micafungin page.
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