Drug interactions
Isavuconazonium + Micafungin
Severity: Minor
Isavuconazonium and Micafungin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Micafungin is a weak CYP3A4 inhibitor, and isavuconazole is a CYP3A4 substrate, so a small rise in isavuconazole exposure is theoretically possible. This is unlikely to be clinically important, and the two antifungals are sometimes used together.
What this interaction means in plain words
Isavuconazonium and Micafungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Micafungin belongs to Anti Fungals.
Why it happens
Theoretical weak CYP3A4 inhibition by micafungin reducing isavuconazole clearance.
What to do
No empirical dose adjustment is needed; monitor for isavuconazole adverse effects such as liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Micafungin
- Lomitapide + Micafungin Moderate
- Micafungin + Saccharomyces boulardii Moderate
- Micafungin + Sirolimus Moderate
- Avapritinib + Micafungin Minor
- Finerenone + Micafungin Minor
- Ivacaftor + Micafungin Minor
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Micafungin?
MediHelp rates the interaction as minor. Isavuconazonium and Micafungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Micafungin is a weak CYP3A4 inhibitor, and isavuconazole is a CYP3A4 substrate, so a small rise in isavuconazole exposure is theoretically possible. This is unlikely to be clinically important, and the two antifungals are sometimes used together.
How serious is the interaction between Isavuconazonium and Micafungin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed; monitor for isavuconazole adverse effects such as liver enzyme elevation.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Lomitapide, Saccharomyces boulardii, Sirolimus. The full list is on the Micafungin page.
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