Drug interactions
Micafungin + Saccharomyces boulardii
Severity: Moderate
Micafungin and Saccharomyces boulardii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Micafungin has activity against yeasts and may reduce the viability of S. boulardii, lessening the probiotic effect. Live yeast probiotics have also caused fungemia in critically ill or catheterized patients.
What this interaction means in plain words
Micafungin and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: antifungal activity against the live yeast probiotic.
What to do
Avoid the probiotic during systemic antifungal therapy, particularly in critically ill patients or those with central lines. Resume only after antifungal treatment is completed if still needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Micafungin and Saccharomyces boulardii, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Micafungin
- Lomitapide + Micafungin Moderate
- Micafungin + Sirolimus Moderate
- Avapritinib + Micafungin Minor
- Finerenone + Micafungin Minor
- Isavuconazonium + Micafungin Minor
- Ivacaftor + Micafungin Minor
Frequently asked questions
Can I take Micafungin with Saccharomyces boulardii?
MediHelp rates the interaction as moderate. Micafungin and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Micafungin has activity against yeasts and may reduce the viability of S. boulardii, lessening the probiotic effect. Live yeast probiotics have also caused fungemia in critically ill or catheterized patients.
How serious is the interaction between Micafungin and Saccharomyces boulardii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the probiotic during systemic antifungal therapy, particularly in critically ill patients or those with central lines. Resume only after antifungal treatment is completed if still needed.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Lomitapide, Sirolimus, Avapritinib. The full list is on the Micafungin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
