Drug interactions
Ivacaftor + Micafungin
Severity: Minor
Ivacaftor and Micafungin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is a sensitive CYP3A4 substrate, and micafungin may weakly inhibit CYP3A4 in vitro. A small increase in ivacaftor exposure is possible but not well documented clinically.
What this interaction means in plain words
Ivacaftor and Micafungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Micafungin belongs to Anti Fungals.
Why it happens
Possible weak CYP3A4 inhibition by micafungin reducing ivacaftor metabolism.
What to do
Dose adjustment is not required for weak inhibitors; monitor for ivacaftor adverse effects such as raised transaminases and headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Micafungin
- Lomitapide + Micafungin Moderate
- Micafungin + Saccharomyces boulardii Moderate
- Micafungin + Sirolimus Moderate
- Avapritinib + Micafungin Minor
- Finerenone + Micafungin Minor
- Isavuconazonium + Micafungin Minor
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Micafungin?
MediHelp rates the interaction as minor. Ivacaftor and Micafungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor is a sensitive CYP3A4 substrate, and micafungin may weakly inhibit CYP3A4 in vitro. A small increase in ivacaftor exposure is possible but not well documented clinically.
How serious is the interaction between Ivacaftor and Micafungin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose adjustment is not required for weak inhibitors; monitor for ivacaftor adverse effects such as raised transaminases and headache.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Lomitapide, Saccharomyces boulardii, Sirolimus. The full list is on the Micafungin page.
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