Drug interactions
Miconazole vaginal + Temsirolimus
Severity: Minor
Miconazole vaginal and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole has low but measurable systemic absorption and can inhibit CYP3A4 in some patients. A meaningful rise in temsirolimus exposure is unlikely with short courses.
What this interaction means in plain words
Miconazole vaginal and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by absorbed miconazole.
What to do
No dose change is usually needed; monitor for temsirolimus adverse effects if prolonged or repeated courses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Miconazole vaginal with Temsirolimus?
MediHelp rates the interaction as minor. Miconazole vaginal and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole has low but measurable systemic absorption and can inhibit CYP3A4 in some patients. A meaningful rise in temsirolimus exposure is unlikely with short courses.
How serious is the interaction between Miconazole vaginal and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for temsirolimus adverse effects if prolonged or repeated courses are used.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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