Drug interactions
Microbiota + Penicillin g
Severity: Moderate
Microbiota and Penicillin g: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral fecal microbiota product contains live bacterial spores that are meant to recolonize the gut. Systemic penicillin can act against these organisms and reduce engraftment, lowering the product's effectiveness.
What this interaction means in plain words
Microbiota and Penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity of penicillin against the live microbiota components reduces colonization (pharmacodynamic antagonism).
What to do
Complete the antibiotic course and wait at least 2 to 4 days before starting oral microbiota, as per product labeling. Do not give them concurrently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
Frequently asked questions
Can I take Microbiota with Penicillin g?
MediHelp rates the interaction as moderate. Microbiota and Penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral fecal microbiota product contains live bacterial spores that are meant to recolonize the gut. Systemic penicillin can act against these organisms and reduce engraftment, lowering the product's effectiveness.
How serious is the interaction between Microbiota and Penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the antibiotic course and wait at least 2 to 4 days before starting oral microbiota, as per product labeling. Do not give them concurrently.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
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