Drug interactions
Midazolam + Nifedipine
Severity: Minor
Midazolam and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is at most a weak CYP3A4 inhibitor, so a clinically significant increase in midazolam exposure is not expected. Additive hypotension and sedation are possible but usually mild.
What this interaction means in plain words
Midazolam and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midazolam belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by nifedipine may marginally reduce midazolam clearance.
What to do
No dose change is needed; monitor sedation level and blood pressure, particularly with intravenous midazolam.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Nifedipine?
MediHelp rates the interaction as minor. Midazolam and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is at most a weak CYP3A4 inhibitor, so a clinically significant increase in midazolam exposure is not expected. Additive hypotension and sedation are possible but usually mild.
How serious is the interaction between Midazolam and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor sedation level and blood pressure, particularly with intravenous midazolam.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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