Drug interactions
Midazolam + Olutasidenib
Severity: Moderate
Midazolam and Olutasidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olutasidenib induces CYP3A4 and can lower midazolam concentrations, with possible loss of sedative effect. Oral midazolam is most affected.
What this interaction means in plain words
Midazolam and Olutasidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Olutasidenib belongs to Oncology.
Why it happens
Olutasidenib induction of CYP3A4 increases midazolam metabolism.
What to do
Monitor for inadequate sedation and titrate midazolam to effect, or select an alternative agent not dependent on CYP3A4. Reassess dosing if olutasidenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Olutasidenib
Frequently asked questions
Can I take Midazolam with Olutasidenib?
MediHelp rates the interaction as moderate. Midazolam and Olutasidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olutasidenib induces CYP3A4 and can lower midazolam concentrations, with possible loss of sedative effect. Oral midazolam is most affected.
How serious is the interaction between Midazolam and Olutasidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for inadequate sedation and titrate midazolam to effect, or select an alternative agent not dependent on CYP3A4. Reassess dosing if olutasidenib is stopped.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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