Drug interactions
Midazolam + Oxybutynin
Severity: Moderate
Midazolam and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybutynin is a CYP3A4 substrate and may slightly compete with midazolam metabolism, but the main concern is additive CNS depression. Anticholinergic effects on cognition and sedation can add to those of midazolam, especially in older adults.
What this interaction means in plain words
Midazolam and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Oxybutynin belongs to Genitourinary.
Why it happens
Additive CNS depressant and anticholinergic effects, with minor competition for CYP3A4 metabolism.
What to do
Use the lowest effective midazolam dose and monitor sedation, respiration and confusion, particularly in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Midazolam and Oxybutynin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Oxybutynin
Frequently asked questions
Can I take Midazolam with Oxybutynin?
MediHelp rates the interaction as moderate. Midazolam and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxybutynin is a CYP3A4 substrate and may slightly compete with midazolam metabolism, but the main concern is additive CNS depression. Anticholinergic effects on cognition and sedation can add to those of midazolam, especially in older adults.
How serious is the interaction between Midazolam and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose and monitor sedation, respiration and confusion, particularly in elderly patients.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
