Drug interactions
Midazolam + Pirtobrutinib
Severity: Moderate
Midazolam and Pirtobrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirtobrutinib weakly inhibits CYP3A4 and can raise midazolam concentrations, increasing and prolonging sedation. The effect is more relevant for oral midazolam.
What this interaction means in plain words
Midazolam and Pirtobrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Pirtobrutinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by pirtobrutinib reduces midazolam metabolism.
What to do
Monitor for excess sedation and consider lowering the midazolam dose, particularly with oral administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Pirtobrutinib
Frequently asked questions
Can I take Midazolam with Pirtobrutinib?
MediHelp rates the interaction as moderate. Midazolam and Pirtobrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirtobrutinib weakly inhibits CYP3A4 and can raise midazolam concentrations, increasing and prolonging sedation. The effect is more relevant for oral midazolam.
How serious is the interaction between Midazolam and Pirtobrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and consider lowering the midazolam dose, particularly with oral administration.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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