Drug interactions
Midazolam + Scopolamine
Severity: Moderate
Midazolam and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and scopolamine adds sedation, confusion and amnesia to the effects of midazolam. Combined use increases the risk of excessive sedation and respiratory depression, especially in older patients.
What this interaction means in plain words
Midazolam and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive CNS depression from benzodiazepine GABA-A potentiation and central anticholinergic action.
What to do
Reduce the midazolam dose and monitor level of consciousness and oxygen saturation; take extra care in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Scopolamine
Frequently asked questions
Can I take Midazolam with Scopolamine?
MediHelp rates the interaction as moderate. Midazolam and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and scopolamine adds sedation, confusion and amnesia to the effects of midazolam. Combined use increases the risk of excessive sedation and respiratory depression, especially in older patients.
How serious is the interaction between Midazolam and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the midazolam dose and monitor level of consciousness and oxygen saturation; take extra care in elderly patients.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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