Drug interactions
Midazolam + Somapacitan
Severity: Minor
Midazolam and Somapacitan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone therapy may increase the activity of some CYP450 enzymes, which could modestly lower exposure to CYP3A substrates such as midazolam. The clinical relevance is uncertain.
What this interaction means in plain words
Midazolam and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midazolam belongs to Central Nervous System; Somapacitan belongs to Endocrine.
Why it happens
Possible growth hormone-mediated increase in CYP3A4 activity; the effect is not well established.
What to do
Monitor midazolam response and adjust the dose if effect is reduced after somapacitan is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Midazolam with Somapacitan?
MediHelp rates the interaction as minor. Midazolam and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone therapy may increase the activity of some CYP450 enzymes, which could modestly lower exposure to CYP3A substrates such as midazolam. The clinical relevance is uncertain.
How serious is the interaction between Midazolam and Somapacitan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor midazolam response and adjust the dose if effect is reduced after somapacitan is started.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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