Drug interactions
Midazolam + Tetracycline
Severity: Minor
Midazolam and Tetracycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline is not an established CYP3A4 inhibitor and no clinically significant effect on midazolam is documented.
What this interaction means in plain words
Midazolam and Tetracycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midazolam belongs to Central Nervous System; Tetracycline belongs to Anti Bacterial.
Why it happens
No established mechanism; theoretical CYP3A4 effect only.
What to do
No specific action required beyond routine sedation monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Midazolam with Tetracycline?
MediHelp rates the interaction as minor. Midazolam and Tetracycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracycline is not an established CYP3A4 inhibitor and no clinically significant effect on midazolam is documented.
How serious is the interaction between Midazolam and Tetracycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action required beyond routine sedation monitoring.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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