Drug interactions
Midazolam + Trimethobenzamide
Severity: Minor
Midazolam and Trimethobenzamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethobenzamide can cause drowsiness and dizziness, which may add to the sedative effect of midazolam. The interaction is usually mild.
What this interaction means in plain words
Midazolam and Trimethobenzamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midazolam belongs to Central Nervous System; Trimethobenzamide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression through independent sedative effects.
What to do
Monitor for increased sedation and adjust the midazolam dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Trimethobenzamide
- Metoclopramide + Trimethobenzamide Moderate
Frequently asked questions
Can I take Midazolam with Trimethobenzamide?
MediHelp rates the interaction as minor. Midazolam and Trimethobenzamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trimethobenzamide can cause drowsiness and dizziness, which may add to the sedative effect of midazolam. The interaction is usually mild.
How serious is the interaction between Midazolam and Trimethobenzamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and adjust the midazolam dose if needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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