Drug interactions
Metoclopramide + Trimethobenzamide
Severity: Moderate
Metoclopramide and Trimethobenzamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are antiemetics with central dopamine-antagonist activity and can cause extrapyramidal reactions and drowsiness. Combined use may increase the risk of movement disorders and sedation.
What this interaction means in plain words
Metoclopramide and Trimethobenzamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Trimethobenzamide belongs to Gastrointestinal Tract.
Why it happens
Additive central dopamine D2 antagonism and CNS depression.
What to do
Avoid combining two dopamine-blocking antiemetics when possible. If both are needed, monitor for extrapyramidal symptoms and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Trimethobenzamide
Frequently asked questions
Can I take Metoclopramide with Trimethobenzamide?
MediHelp rates the interaction as moderate. Metoclopramide and Trimethobenzamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are antiemetics with central dopamine-antagonist activity and can cause extrapyramidal reactions and drowsiness. Combined use may increase the risk of movement disorders and sedation.
How serious is the interaction between Metoclopramide and Trimethobenzamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dopamine-blocking antiemetics when possible. If both are needed, monitor for extrapyramidal symptoms and sedation.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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