Drug interactions
Midazolam intranasal + Nevirapine
Severity: Minor
Midazolam intranasal and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine is an inducer of CYP3A4, so midazolam exposure is expected to decrease rather than increase. Seizure rescue efficacy may be somewhat reduced.
What this interaction means in plain words
Midazolam intranasal and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nevirapine induces CYP3A4, increasing midazolam clearance.
What to do
Monitor response to intranasal midazolam and be prepared to give additional or alternative rescue therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Midazolam intranasal with Nevirapine?
MediHelp rates the interaction as minor. Midazolam intranasal and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine is an inducer of CYP3A4, so midazolam exposure is expected to decrease rather than increase. Seizure rescue efficacy may be somewhat reduced.
How serious is the interaction between Midazolam intranasal and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to intranasal midazolam and be prepared to give additional or alternative rescue therapy.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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