Drug interactions
Midazolam intranasal + Ranolazine
Severity: Moderate
Midazolam intranasal and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine weakly inhibits CYP3A4 and may increase midazolam exposure, prolonging sedation. The effect is modest but relevant for respiratory depression risk.
What this interaction means in plain words
Midazolam intranasal and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ranolazine inhibits CYP3A4 metabolism of midazolam.
What to do
Monitor sedation and respiratory status after intranasal midazolam and avoid repeat dosing earlier than labeled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Midazolam intranasal with Ranolazine?
MediHelp rates the interaction as moderate. Midazolam intranasal and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine weakly inhibits CYP3A4 and may increase midazolam exposure, prolonging sedation. The effect is modest but relevant for respiratory depression risk.
How serious is the interaction between Midazolam intranasal and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after intranasal midazolam and avoid repeat dosing earlier than labeled.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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