Drug interactions
Midazolam intranasal + Temsirolimus
Severity: Minor
Midazolam intranasal and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus is not recognized as a clinically significant CYP3A4 inhibitor, so a meaningful rise in midazolam exposure is unlikely. Any effect would be additive sedation at most.
What this interaction means in plain words
Midazolam intranasal and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 effect; not established as clinically relevant.
What to do
No dose adjustment is needed; observe for the usual duration of sedation after intranasal midazolam.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Midazolam intranasal with Temsirolimus?
MediHelp rates the interaction as minor. Midazolam intranasal and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Temsirolimus is not recognized as a clinically significant CYP3A4 inhibitor, so a meaningful rise in midazolam exposure is unlikely. Any effect would be additive sedation at most.
How serious is the interaction between Midazolam intranasal and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; observe for the usual duration of sedation after intranasal midazolam.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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