Drug interactions
Midazolam intranasal + Trazodone
Severity: Moderate
Midazolam intranasal and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is a weak CYP3A4 inhibitor and may modestly raise midazolam exposure, and both drugs also cause sedation. This can prolong or deepen sedation and impair psychomotor performance.
What this interaction means in plain words
Midazolam intranasal and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression plus weak CYP3A4 inhibition that may slow midazolam metabolism.
What to do
Use the lowest effective midazolam dose and monitor sedation and respiratory status. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Midazolam intranasal with Trazodone?
MediHelp rates the interaction as moderate. Midazolam intranasal and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone is a weak CYP3A4 inhibitor and may modestly raise midazolam exposure, and both drugs also cause sedation. This can prolong or deepen sedation and impair psychomotor performance.
How serious is the interaction between Midazolam intranasal and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose and monitor sedation and respiratory status. Advise patients to avoid driving and alcohol.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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