Drug interactions
Midazolam intranasal + Zonisamide
Severity: Moderate
Midazolam intranasal and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zonisamide and midazolam both depress the central nervous system. Using them together can intensify sedation and, in vulnerable patients, may contribute to respiratory depression.
What this interaction means in plain words
Midazolam intranasal and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic CNS and respiratory depression.
What to do
Monitor sedation and respiratory status after midazolam is administered, especially in patients with respiratory compromise. Use the lowest effective midazolam dose and make sure there is someone to observe the patient.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Midazolam intranasal with Zonisamide?
MediHelp rates the interaction as moderate. Midazolam intranasal and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zonisamide and midazolam both depress the central nervous system. Using them together can intensify sedation and, in vulnerable patients, may contribute to respiratory depression.
How serious is the interaction between Midazolam intranasal and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after midazolam is administered, especially in patients with respiratory compromise. Use the lowest effective midazolam dose and make sure there is someone to observe the patient.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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