Drug interactions
Midodrine + Norepinephrine
Severity: Moderate
Midodrine and Norepinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise blood pressure through alpha-1 adrenergic vasoconstriction, so combined use can cause excessive hypertension and reflex bradycardia. This matters most in patients with cardiovascular disease or those who are also supine.
What this interaction means in plain words
Midodrine and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive alpha-adrenergic agonist vasopressor effects.
What to do
Monitor blood pressure and heart rate continuously and titrate the norepinephrine infusion down as midodrine takes effect. Reduce or hold midodrine if hypertension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Midodrine and Norepinephrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Norepinephrine?
MediHelp rates the interaction as moderate. Midodrine and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs raise blood pressure through alpha-1 adrenergic vasoconstriction, so combined use can cause excessive hypertension and reflex bradycardia. This matters most in patients with cardiovascular disease or those who are also supine.
How serious is the interaction between Midodrine and Norepinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously and titrate the norepinephrine infusion down as midodrine takes effect. Reduce or hold midodrine if hypertension or bradycardia develops.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
