Drug interactions
Midodrine + Phendimetrazine
Severity: Moderate
Midodrine and Phendimetrazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic and midodrine is an alpha-1 agonist, so together they can produce additive increases in blood pressure. Palpitations, tachycardia or marked hypertension may occur, especially in patients with cardiovascular disease.
What this interaction means in plain words
Midodrine and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic pressor effects via direct alpha-1 agonism and indirect norepinephrine release.
What to do
Monitor blood pressure and heart rate, including supine readings, and reduce midodrine dose if hypertension occurs. Avoid the combination in uncontrolled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Phendimetrazine?
MediHelp rates the interaction as moderate. Midodrine and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic and midodrine is an alpha-1 agonist, so together they can produce additive increases in blood pressure. Palpitations, tachycardia or marked hypertension may occur, especially in patients with cardiovascular disease.
How serious is the interaction between Midodrine and Phendimetrazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, including supine readings, and reduce midodrine dose if hypertension occurs. Avoid the combination in uncontrolled hypertension.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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