Drug interactions
Midodrine + Phenylephrine po
Severity: Moderate
Midodrine and Phenylephrine po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral phenylephrine is an alpha-1 agonist, so combining it with midodrine can cause additive vasoconstriction and a rise in blood pressure. Reflex bradycardia and supine hypertension are possible.
What this interaction means in plain words
Midodrine and Phenylephrine po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive alpha-1 adrenergic agonist effects.
What to do
Avoid unnecessary decongestant use in midodrine-treated patients; if used, monitor blood pressure including supine readings and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Phenylephrine po?
MediHelp rates the interaction as moderate. Midodrine and Phenylephrine po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral phenylephrine is an alpha-1 agonist, so combining it with midodrine can cause additive vasoconstriction and a rise in blood pressure. Reflex bradycardia and supine hypertension are possible.
How serious is the interaction between Midodrine and Phenylephrine po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary decongestant use in midodrine-treated patients; if used, monitor blood pressure including supine readings and heart rate.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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