Drug interactions
Midodrine + Pimozide
Severity: Minor
Midodrine and Pimozide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist that raises blood pressure and can cause reflex bradycardia, while pimozide blocks alpha receptors and can prolong QT. Bradycardia is a risk factor for torsades with pimozide, though a clinically significant interaction is not well documented.
What this interaction means in plain words
Midodrine and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midodrine belongs to Miscellaneous; Pimozide belongs to Central Nervous System.
Why it happens
Opposing alpha-adrenergic effects; midodrine-induced bradycardia may add to pimozide's arrhythmic risk, though the mechanism is not firmly established.
What to do
Monitor heart rate and blood pressure when the drugs are combined. Obtain an ECG if bradycardia or symptoms such as syncope occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Pimozide?
MediHelp rates the interaction as minor. Midodrine and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midodrine is an alpha-1 agonist that raises blood pressure and can cause reflex bradycardia, while pimozide blocks alpha receptors and can prolong QT. Bradycardia is a risk factor for torsades with pimozide, though a clinically significant interaction is not well documented.
How serious is the interaction between Midodrine and Pimozide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when the drugs are combined. Obtain an ECG if bradycardia or symptoms such as syncope occur.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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