Drug interactions
Midodrine + Pirbuterol
Severity: Moderate
Midodrine and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have adrenergic agonist activity, so together they may cause additive increases in blood pressure and heart rate. Supine hypertension and palpitations are of particular concern with midodrine.
What this interaction means in plain words
Midodrine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic effects: alpha-1 agonism from midodrine and beta-2 agonism from pirbuterol.
What to do
Monitor blood pressure, including supine readings, and heart rate. Reduce doses if hypertension or tachycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Pirbuterol?
MediHelp rates the interaction as moderate. Midodrine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have adrenergic agonist activity, so together they may cause additive increases in blood pressure and heart rate. Supine hypertension and palpitations are of particular concern with midodrine.
How serious is the interaction between Midodrine and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, and heart rate. Reduce doses if hypertension or tachycardia develops.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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