Drug interactions
Midodrine + Tenofovir df
Severity: Minor
Midodrine and Tenofovir df: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desglymidodrine is eliminated partly by renal tubular secretion, and tenofovir is also actively secreted by the kidney. Competition could raise exposure to either drug, though clinical data are scarce.
What this interaction means in plain words
Midodrine and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion transporters.
What to do
No routine change is needed; monitor blood pressure and renal function in patients with reduced kidney function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Tenofovir df?
MediHelp rates the interaction as minor. Midodrine and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desglymidodrine is eliminated partly by renal tubular secretion, and tenofovir is also actively secreted by the kidney. Competition could raise exposure to either drug, though clinical data are scarce.
How serious is the interaction between Midodrine and Tenofovir df?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood pressure and renal function in patients with reduced kidney function.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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