Drug interactions
Midodrine + Tenofovir disoproxil
Severity: Minor
Midodrine and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of midodrine, desglymidodrine, is renally secreted, so competition at tubular transporters with tenofovir is theoretically possible. Clinical data are lacking, and the effect is expected to be small.
What this interaction means in plain words
Midodrine and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical competition for renal tubular secretion; not well characterized.
What to do
No empirical dose change is needed. Monitor blood pressure, especially supine hypertension, and renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Midodrine and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The active metabolite of midodrine, desglymidodrine, is renally secreted, so competition at tubular transporters with tenofovir is theoretically possible. Clinical data are lacking, and the effect is expected to be small.
How serious is the interaction between Midodrine and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor blood pressure, especially supine hypertension, and renal function.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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