Drug interactions
Midodrine + Terbutaline
Severity: Moderate
Midodrine and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist that raises blood pressure, and terbutaline adds beta-adrenergic cardiac stimulation. Together they may increase blood pressure and heart rate or provoke palpitations and arrhythmias in susceptible patients.
What this interaction means in plain words
Midodrine and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Terbutaline belongs to Respiratory.
Why it happens
Additive sympathomimetic effects: alpha-1 vasoconstriction from midodrine and beta-2 mediated cardiac stimulation from terbutaline.
What to do
Monitor blood pressure and heart rate, including supine hypertension with midodrine. Adjust doses if cardiovascular effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Terbutaline?
MediHelp rates the interaction as moderate. Midodrine and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist that raises blood pressure, and terbutaline adds beta-adrenergic cardiac stimulation. Together they may increase blood pressure and heart rate or provoke palpitations and arrhythmias in susceptible patients.
How serious is the interaction between Midodrine and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, including supine hypertension with midodrine. Adjust doses if cardiovascular effects develop.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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