Drug interactions
Midodrine + Xylometazoline
Severity: Moderate
Midodrine and Xylometazoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist used to raise blood pressure, and xylometazoline is also an alpha agonist. Together they may produce additive vasoconstriction, causing hypertension and reflex bradycardia. Supine hypertension is already a concern with midodrine.
What this interaction means in plain words
Midodrine and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Xylometazoline belongs to Respiratory.
Why it happens
Additive alpha-adrenergic agonist vasoconstrictor effects.
What to do
Monitor blood pressure including supine readings and avoid regular use of decongestants. Reduce or stop the decongestant if blood pressure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Xylometazoline
- Selegiline + Xylometazoline Contraindicated
- Ergotamine + Xylometazoline Major
- Isocarboxazid + Xylometazoline Major
- Phenelzine + Xylometazoline Major
- Tranylcypromine + Xylometazoline Major
- Amitriptyline + Xylometazoline Moderate
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Xylometazoline?
MediHelp rates the interaction as moderate. Midodrine and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist used to raise blood pressure, and xylometazoline is also an alpha agonist. Together they may produce additive vasoconstriction, causing hypertension and reflex bradycardia. Supine hypertension is already a concern with midodrine.
How serious is the interaction between Midodrine and Xylometazoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including supine readings and avoid regular use of decongestants. Reduce or stop the decongestant if blood pressure rises.
What other medicines interact with Xylometazoline?
MediHelp also lists interactions of Xylometazoline with, for example, Selegiline, Ergotamine, Isocarboxazid. The full list is on the Xylometazoline page.
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