Drug interactions
Midodrine + Yohimbe
Severity: Major
Midodrine and Yohimbe: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe contains yohimbine, an alpha-2 antagonist that increases sympathetic outflow and can raise blood pressure. Combined with midodrine, hypertensive episodes may occur.
What this interaction means in plain words
Midodrine and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pressor effects: direct alpha-1 agonism by midodrine plus increased noradrenergic tone from alpha-2 blockade by yohimbine.
What to do
Advise patients to avoid yohimbe products while taking midodrine. If exposure occurs, monitor blood pressure and heart rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Yohimbe?
MediHelp rates the interaction as major. Midodrine and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yohimbe contains yohimbine, an alpha-2 antagonist that increases sympathetic outflow and can raise blood pressure. Combined with midodrine, hypertensive episodes may occur.
How serious is the interaction between Midodrine and Yohimbe?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe products while taking midodrine. If exposure occurs, monitor blood pressure and heart rate.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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