Drug interactions
Midodrine + Yohimbine
Severity: Moderate
Midodrine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist that raises blood pressure, and yohimbine is an alpha-2 antagonist that increases noradrenergic outflow. Used together they can produce additive pressor effects, with hypertension, tachycardia, palpitations and anxiety.
What this interaction means in plain words
Midodrine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic effects from direct alpha-1 agonism (midodrine) and increased norepinephrine release through alpha-2 blockade (yohimbine).
What to do
Avoid combining where possible; if used together, monitor blood pressure and heart rate, including supine readings, and reduce or stop one agent if hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Yohimbine?
MediHelp rates the interaction as moderate. Midodrine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist that raises blood pressure, and yohimbine is an alpha-2 antagonist that increases noradrenergic outflow. Used together they can produce additive pressor effects, with hypertension, tachycardia, palpitations and anxiety.
How serious is the interaction between Midodrine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if used together, monitor blood pressure and heart rate, including supine readings, and reduce or stop one agent if hypertension develops.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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