Drug interactions
Midostaurin + Olanzapine
Severity: Moderate
Midostaurin and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin has been associated with QT prolongation, and olanzapine may contribute additively. This can increase the risk of arrhythmia.
What this interaction means in plain words
Midostaurin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midostaurin belongs to Oncology; Olanzapine belongs to Central Nervous System.
Why it happens
Additive prolongation of the QT interval.
What to do
Monitor the ECG and electrolytes during concurrent use. Consider an alternative antipsychotic if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Midostaurin
Frequently asked questions
Can I take Midostaurin with Olanzapine?
MediHelp rates the interaction as moderate. Midostaurin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midostaurin has been associated with QT prolongation, and olanzapine may contribute additively. This can increase the risk of arrhythmia.
How serious is the interaction between Midostaurin and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes during concurrent use. Consider an alternative antipsychotic if the QTc becomes prolonged.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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