Drug interactions
Mifepristone + Naldemedine
Severity: Moderate
Mifepristone and Naldemedine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase naldemedine concentrations. Higher exposure may increase gastrointestinal adverse effects such as abdominal pain and diarrhea, and possibly opioid withdrawal symptoms.
What this interaction means in plain words
Mifepristone and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Mifepristone inhibits CYP3A4, reducing the metabolism of naldemedine.
What to do
Monitor for gastrointestinal effects and opioid withdrawal symptoms. Consider stopping naldemedine if these become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Mifepristone with Naldemedine?
MediHelp rates the interaction as moderate. Mifepristone and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase naldemedine concentrations. Higher exposure may increase gastrointestinal adverse effects such as abdominal pain and diarrhea, and possibly opioid withdrawal symptoms.
How serious is the interaction between Mifepristone and Naldemedine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal effects and opioid withdrawal symptoms. Consider stopping naldemedine if these become troublesome.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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