Drug interactions
Mifepristone + Naloxegol
Severity: Major
Mifepristone and Naloxegol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naloxegol is a CYP3A4 and P-glycoprotein substrate, and mifepristone is a CYP3A4 inhibitor. Increased naloxegol exposure can cause opioid withdrawal symptoms, abdominal pain and diarrhea.
What this interaction means in plain words
Mifepristone and Naloxegol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of naloxegol, raising its plasma concentrations.
What to do
Avoid the combination; use an alternative laxative strategy. If unavoidable, consider a reduced naloxegol dose and monitor for withdrawal and GI effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mifepristone and Naloxegol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Mifepristone with Naloxegol?
MediHelp rates the interaction as major. Mifepristone and Naloxegol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Naloxegol is a CYP3A4 and P-glycoprotein substrate, and mifepristone is a CYP3A4 inhibitor. Increased naloxegol exposure can cause opioid withdrawal symptoms, abdominal pain and diarrhea.
How serious is the interaction between Mifepristone and Naloxegol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative laxative strategy. If unavoidable, consider a reduced naloxegol dose and monitor for withdrawal and GI effects.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
