Drug interactions
Mifepristone + Nicardipine
Severity: Moderate
Mifepristone and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase nicardipine concentrations. This can cause excessive hypotension, flushing, headache, and edema.
What this interaction means in plain words
Mifepristone and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Nicardipine belongs to Cardiovascular.
Why it happens
Mifepristone inhibits CYP3A4, reducing nicardipine metabolism.
What to do
Monitor blood pressure and start nicardipine at a low dose, titrating cautiously. Reduce the dose if hypotension or vasodilatory effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Nicardipine?
MediHelp rates the interaction as moderate. Mifepristone and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase nicardipine concentrations. This can cause excessive hypotension, flushing, headache, and edema.
How serious is the interaction between Mifepristone and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and start nicardipine at a low dose, titrating cautiously. Reduce the dose if hypotension or vasodilatory effects develop.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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