Drug interactions
Mifepristone + Oliceridine
Severity: Major
Mifepristone and Oliceridine: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone can increase oliceridine concentrations through CYP3A4 inhibition. This may cause deeper sedation and respiratory depression, and stopping the inhibitor may lead to reduced analgesia.
What this interaction means in plain words
Mifepristone and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Oliceridine belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated oliceridine metabolism by mifepristone.
What to do
Monitor closely for respiratory depression and sedation and extend dosing intervals or reduce doses as needed. Reassess analgesic dosing if mifepristone is discontinued.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Mifepristone with Oliceridine?
MediHelp rates the interaction as major. Mifepristone and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone can increase oliceridine concentrations through CYP3A4 inhibition. This may cause deeper sedation and respiratory depression, and stopping the inhibitor may lead to reduced analgesia.
How serious is the interaction between Mifepristone and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for respiratory depression and sedation and extend dosing intervals or reduce doses as needed. Reassess analgesic dosing if mifepristone is discontinued.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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